Uncovering Pediatric Long COVID (2024)

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    August21, 2024

    SuchitraRao,MBBS, MSCS1

    Author Affiliations Article Information

    • 1Department of Pediatrics, University of Colorado School of Medicine and Children’s Hospital Colorado, Aurora

    JAMA. Published online August 21, 2024. doi:10.1001/jama.2024.13551

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    • Original Investigation Characterizing Long COVID in Children and Adolescents

      Rachel S.Gross,MD, MS; TanayottThaweethai,PhD; Lawrence C.Kleinman,MD, MPH; Jessica N.Snowden,MD; Erika B.Rosenzweig,MD; Joshua D.Milner,MD; Kelan G.Tantisira,MD, MPH; Kyung E.Rhee,MD, MSc, MA; Terry L.Jernigan,PhD; Patricia A.Kinser,PhD; Amy L.Salisbury,PhD; DavidWarburton,DSc, MD; SindhuMohandas,MD; John C.Wood,MD, PhD; Jane W.Newburger,MD; Dongngan T.Truong,MD, MS; Valerie J.Flaherman,MD, MPH; Torri D.Metz,MD, MS; Elizabeth W.Karlson,MD; Lori B.Chibnik,PhD, MPH; Deepti B.Pant,MPH; AparnaKrishnamoorthy,MS; RichardGallagher,PhD; Michelle F.Lamendola-Essel,DHSc, MS; Denise C.Hasson,MD; Stuart D.Katz,MD; ShonnaYin,MD, MSc; Benard P.Dreyer,MD; MeganCarmilani,MEd; K.Coombs,MTCM, Ac; Megan L.Fitzgerald,PhD; NickGüthe,BA; MadyHornig,MD; Rebecca J.Letts,BA; Aimee K.Peddie,BS; Brittany D.Taylor,MPH; Andrea S.Foulkes,ScD; Melissa S.Stockwell,MD, MPH; RECOVER-Pediatrics Consortium; RECOVER-Pediatrics Group Authors; VenkataramanBalaraman; AmandaBogie; HulyaBukulmez; Allen J.Dozor; DanielEckrich; Amy J.Elliott; Danielle N.Evans; Jonathan S.Farkas; E. Vincent S.Faustino; LauraFischer; SunandaGaur; Ashraf S.Harahsheh; Uzma N.Hasan; Daniel S.Hsia; GrediaHuerta-Montanez; Kathy D.Hummel; Matt P.Kadish; David C.Kaelber; SankaranKrishnan; Jessica S.Kosut; JerryLarrabee; Peter Paul C.Lim; Ian C.Michelow; Carlos R.Oliveira; HengamehRaissy; ZairaRosario-Pabon; Judith L.Ross; Alice I.Sato; Michelle D.Stevenson; Maria M.Talavera-Barber; Ronald J.TeufelII; Kathryn E.Weakley; EmilyZimmerman; Marie-Abele C.Bind; JamesChan; ZoeGuan; Richard E.Morse; Harrison T.Reeder; NataschaAkshoomoff; Judy L.Aschner; RakeshBhattacharjee; Lesley A.Cottrell; KellyCowan; Viren A.D'Sa; Alexander G.Fiks; Maria L.Gennaro; KatherineIrby; ManaswithaKhare; JeremyLandeo Guttierrez; Russell J.McCulloh; ShaluNarang; ManetteNess- Cochinwala; SheilaNolan; PaulPalumbo; JulieRyu; Juan C.Salazar; RangarajSelvarangan; Cheryl R.Stein; AlanWerzberger; William T.Zempsky; RobinAupperle; Fiona C.Baker; Marie T.Banich; Deanna M.Barch; ArielleBaskin-Sommers; James M.Bjork; Susan Y.Bookheimer; Sandra A.Brown; BJCasey; LindaChang; Duncan B.Clark; Anders M.Dale; MirellaDapretto; Thomas M.Ernst; Damien A.Fair; Sarah W.Feldstein Ewing; John J.Foxe; Edward G.Freedman; Naomi P.Friedman; HughGaravan; Dylan G.Gee; RaulGonzalez; Kevin M.Gray; Mary M.Heitzeg; Megan M.Herting; JoannaJacobus; Angela R.Laird; Christine L.Larson; Krista M.Lisdahl; MonicaLuciana; BeatrizLuna; Pamela A.F.Madden; Erin C.McGlade; Eva M.Müller-Oehring; Bonnie J.Nagel; Michael C.Neale; Martin P.Paulus; Alexandra S.Potter; Perry F.Renshaw; Elizabeth R.Sowell; Lindsay M.Squeglia; SusanTapert; Lucina Q.Uddin; SyliaWilson; Deborah A.Yurgelun-Todd; Jessica N.Snowden; Paul M.Darden; LexieDixon; AmalAhmed; ConnorGarbe; LauraHobart-Porter; AlmaryAkerlundh; LeeHoward; KathyHummel; HannahKrehbiel; HaleySpradlin; PaulaYount; AkramAlshawabkeh; JudithRoss; CarolMcDevitt; DanEckrich; BrettAnderson; ChijokeIkomi; CheyenneKatz; DanielleKatz; JudyAschner; KarenKowal; MarisaMeyer; AndyAtz; AndrewAtz; ConnieNguyen; GwenPellicciotti; Thao-LyPhan; KarenRavin; VictoriaReynolds; FionaBaker; AnnetteBaker; AbigailStrang; DeepikaThacker; AnnabelleGoetter; DithiBanerjee; DeannaBarch; JoAnnCheung; Travis K.F.Hong; ShanelleKalua; EvanMinami; AndreaSiu; MicahTong; BayleaAlbarado; TraceyAllen; AllisonAttuso; TaylorAyers; EmilyBebler; GraceBella; AlexaBennett; JohnBrown; RyanBrown; AlexisBrown; SandraBrown; AlisonCarville; JamesBjork; SydnieDarby; KaraDevall; AmberDragg; AngelaElderedge; ElisabethFontenot; GretaFry; BethanyGildersleeve; SaraGoff; LaurenHarrington; JackieBoyd; LisaJones; VictoriaKaiser; CassidyKaiser; YejeeLee; StephenLee; DonnaLee; ErinLeJeune; RobertLeonhard; JenniferLevatino; Natalie C.Buchbinder; DonaldLewis; AngrielleLloyd; RonMonce; SusannahMunro; MeghanPhillips; BlairPucheu; EmilyRachal; JenniferRood; StaceyRoussel; ReneeRumsey; ConnorSanford; VirginiaCasey; MonicaSantos; MelissaSantos; AryelleStafford; NormaCastro; AmyThomassie; CelesteWaguespack; KatherineWalgamotte; MeredithWelch; AubreyWindham; MichelleStevenson; 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Vincent S.Faustino,MD, MHS; LauraFischer,MPH; SunandaGaur,MD; Ashraf S.Harahsheh,MD; Uzma N.Hasan,MD; Daniel S.Hsia,MD; GrediaHuerta-Montañez,MD; Kathy D.Hummel,MSN; Matt P.Kadish,MD; David C.Kaelber,MD, MPH; SankaranKrishnan,MD, MPH; Jessica S.Kosut,MD; JerryLarrabee,MD; Peter Paul C.Lim,MD; Ian C.Michelow,MD; Carlos R.Oliveira,MD, PhD; HengamehRaissy,PharmD; ZairaRosario-Pabon,MS; Judith L.Ross,MD; Alice I.Sato,MD, PhD; Michelle D.Stevenson,MD, MS; Maria M.Talavera-Barber,DO; Ronald J.Teufel,MD, MSCR; Kathryn E.Weakley,MD, MSc; EmilyZimmerman,PhD, CCC-SLP; Marie-Abele C.Bind,PhD; JamesChan,MA; ZoeGuan,PhD; Richard E.Morse,BA; Harrison T.Reeder,PhD; NataschaAkshoomoff,PhD; Judy L.Aschner,MD; RakeshBhattacharjee,MD; Lesley A.Cottrell,PhD; KellyCowan,MD; Viren A.D'Sa,MD; Alexander G.Fiks,MD, MSCE; Maria L.Gennaro,MD; KatherineIrby,MD; ManaswithaKhare,MD; Jeremy LandeoGuttierrez,MD, MPH; Russell J.McCulloh,MD, MS; ShaluNarang,MD; ManetteNess-Cochinwala,MD; SheilaNolan,MD; PaulPalumbo,MD; JulieRyu,MD; Juan C.Salazar,MD, MPH; RangarajSelvarangan,PhD; Cheryl R.Stein,PhD; AlanWerzberger,MD; William T.Zempsky,MD, MPH; RobinAupperle,PhD; Fiona C.Baker,PhD; Marie T.Banich,PhD; Deanna M.Barch,PhD; ArielleBaskin-Sommers,PhD; James M.Bjork,PhD; Susan Y.Bookheimer,PhD; Sandra A.Brown,PhD; BJCasey,PhD; LindaChang,MD; Duncan B.Clark,MD, PhD; Anders M.Dale,PhD; MirellaDapretto,PhD; Thomas M.Ernst,PhD; Damien A.Fair,PA-C, PhD; Sarah W.Feldstein Ewing,PhD; John J.Foxe,PhD; Edward G.Freedman,PhD; Naomi P.Friedman,PhD; HughGaravan,PhD; Dylan G.Gee,PhD; RaulGonzalez,PhD; Kevin M.Gray,MD; Mary M.Heitzeg,PhD; Megan M.Herting,PhD; JoannaJacobus,PhD; Angela R.Laird,PhD; Christine L.Larson,PhD; Krista M.Lisdahl,PhD; MonicaLuciana,PhD; BeatrizLuna,PhD; Pamela A.F.Madden,PhD; Erin C.McGlade,PhD; Eva M.Müller-Oehring,PhD; Bonnie J.Nagel,PhD; Michael C.Neale,PhD; Martin P.Paulus,PhD; Alexandra S.Potter,PhD; Perry F.Renshaw,MD, PhD; Elizabeth R.Sowell,PhD; Lindsay M.Squeglia,PhD; SusanTapert,PhD; Lucina Q.Uddin,PhD; SyliaWilson,PhD; Deborah A.Yurgelun-Todd,PhD

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    Long COVID in Children

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    The COVID-19 pandemic has had devastating consequences globally, and the immediate and short-term consequences of SARS-CoV-2 infection have been well described. Although most individuals recover, many endure longer-lasting effects, referred to as long COVID, post-COVID condition, or postacute sequelae of SARS-CoV-2 (PASC). PASC is composed of a heterogeneous collection of symptoms and conditions that can affect virtually any organ system, with common manifestations including fatigue, cough, malaise, and pain.1,2 Those at increased risk for long COVID include females, those hospitalized due to acute COVID-19,3,4 and individuals with underlying comorbidities.5-8 Several hypotheses have been proposed to explain the underlying pathophysiology, which is likely multifactorial, including immune dysregulation, autoimmunity and immune printing, microvascular clotting with endothelial dysfunction, and impaired neurological signaling.9,10

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    Rao S. Uncovering Long COVID in Children. JAMA. Published online August 21, 2024. doi:10.1001/jama.2024.13551

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